American Society of Microbiology ASM-ABMM ABMM

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American Society of Microbiology ABMM Sample Questions:

1. A clinical microbiology laboratory is monitoring the emergence of resistance to colistin in Gram-negative bacteria. Resistance to colistin is often mediated by modifications of the bacterial lipopolysaccharide (LPS).
The genetic basis for acquired colistin resistance most commonly involves:

A) Mutations in genes encoding enzymes that modify the lipid A component of LPS.
B) Production of enzymes that directly inactivate the colistin molecule.
C) Alterations in the outer membrane porin proteins, reducing colistin uptake.
D) Acquisition of genes encoding efflux pumps that specifically target colistin.

2. A patient with a history of inflammatory bowel disease is diagnosed with primary sclerosing cholangitis and undergoes liver transplantation. Post-transplant, they develop a bloodstream infection with a Gram-negative bacterium that is identified as Fusobacterium nucleatum. This organism's role in the pathogenesis of colorectal cancer is primarily attributed to its ability to:

A) Produce potent exotoxins that damage the intestinal epithelium.
B) Modulate the host immune response and promote a pro-inflammatory microenvironment.
C) Directly induce mutations in colonic epithelial cells.
D) Form biofilms that physically obstruct the bile ducts.

3. A traveler returning from Southeast Asia presents with fever, headache, and a maculopapular rash that started on the trunk and spread to the extremities, including the palms and soles. Serological testing is positive for Orientia tsutsugamushi. The vector responsible for transmitting this organism is a:

A) Mite (chigger)
B) Mosquito
C) Tick
D) Flea

4. Lyme disease, characterized initially by erythema migrans, is caused by Borrelia burgdorferi. What is the primary arthropod vector responsible for transmitting this spirochete to humans in the Northeastern United States?

A) Amblyomma americanum (Lone Star tick)
B) Dermacentor variabilis (American dog tick)
C) Ixodes scapularis (Blacklegged tick)
D) Pulex irritans (Human flea)

5. An elderly patient in a long-term care facility develops a localized outbreak of painful vesicles along a dermatome. Tzanck smear of a vesicle reveals multinucleated giant cells. The MOST likelycausative agent is:

A) Orf virus
B) Varicella-zoster virus
C) Coxsackievirus
D) Herpes simplex virus type 1

Solutions: